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July 26, 2026BiologyOpen Access

IGF2-H19 Locus Expression Profile and Biomarker Potential in Oral Cancer

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Authors

GSGoran StojkovićMKMilica Jakšić KarišikNTNikola Todorovic

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Overview

Randomized trial analyzes IGF2-H19 locus as a biomarker for oral cancer, suggesting its diagnostic potential.

Key Points

  • The study investigates the expression profile of the IGF2-H19 locus and its biomarker potential in oral cancer.
  • Analyzed IGF2 and H19 expression in oral cancer and normal keratinocyte cell lines.
  • Examined cancer tissue and adjacent non-cancerous tissue from 55 patients with oral cancer.
  • Evaluated the ability of IGF2, H19, and hsa-miR-675-5p to discriminate between cancerous and non-cancerous tissues.
  • IGF2 and H19 expression increased in oral cancer cell lines compared to normal controls.
  • Expression of IGF2-H19 and hsa-miR-675-5p significantly lower in cancerous tissue than adjacent non-cancerous tissue.
  • Combined analysis of IGF2, H19, and hsa-miR-675-5p improved diagnostic performance between oral cancer and non-cancerous tissues.

Cite This Study

Stojković et al. (2026) studied this question.

synapsesocial.com/papers/6a65a36cd3aea3239cd76978https://doi.org/10.3390/biology15151221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comprehensive Pan-Cancer Analysis Revealing IGF2 Gene as a Diagnostic and Prognostic Biomarker2026
  2. 2H19 and IGF2 imprinting from embryogenesis to oncogenesis2026
  3. 3Exploring the Clinical Significance of Circulating H19 lncRNA and IGF-2 mRNA in Colorectal Carcinoma2025
  4. 4HMGA2 Overexpression Is Associated with Poor Prognosis and EGFR Signaling Activation in Oral Squamous Cell Carcinoma2026
  5. 5Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma2022 · 11 citations