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October 10, 2022Frontiers in EndocrinologyOpen Access

Proteomic analysis identified 433 upregulated and 61 downregulated proteins in laryngeal cancer tissues compared to normal tissues, with IGF2R being significantly overexpressed.

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Population

10 tumor and 9 non-tumor samples from laryngeal cancer patients, supplemented by data from The Cancer Genome…

Comparison

Proteomic analysis, gene expression analysis… vs Non-tumor/normal tissues

Design

Preclinical

Key result

Proteomic analysis identified 433 upregulated and 61 downregulated proteins in laryngeal cancer tissues compared to normal tissues, with IGF2R being significantly overexpressed.

Authors

BLBing LiuYHYuqiang HuLWLixia Wan

Discussion

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Overview

IGF2R upregulation in laryngeal tumors suggests a potential target; hypothesis-generating for therapies, requiring validation before any practice change.

Study Design

Type

Observational (n=10)

Multicenter

No

Structured PICO

P
Population
10 patients with biopsy-confirmed T2-T3N0M0 laryngeal cancer without prior treatment who provided paired tumor and adjacent normal tissues for proteomic analysis.
E
Exposure
Proteomic analysis (label-free technique), gene expression analysis, and immunohistochemistry
C
Comparator
Non-tumor/normal tissues
O
Outcome
Protein and gene expression variations between laryngeal squamous cell carcinoma and normal tissuessurrogate

Main Result

p-value: p=<0.05

Proteomic and transcriptomic analyses identify IGF2R as significantly upregulated in laryngeal carcinoma, suggesting its potential as a therapeutic target.

Limitations

  • Small sample size in the proteomics analysis, preventing further stratification based on clinical pathological characteristics.
  • IGF2R was not studied in vitro, limiting in-depth comprehension of its role in laryngeal cancer invasion and metastasis.

Cite This Study

Liu et al. (2022) conducted an observational in Laryngeal cancer (n=10). Laryngeal cancer vs. Adjacent normal tissue was evaluated on Differentially expressed proteins between tumor and non-tumor samples (p=<0.05). Proteomic analysis identified 433 upregulated and 61 downregulated proteins in laryngeal cancer tissues compared to normal tissues, with IGF2R being significantly overexpressed.

synapsesocial.com/papers/6ab244a15b93fa4bb58c8f8ahttps://doi.org/10.3389/fendo.2022.1031210
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comprehensive Pan-Cancer Analysis Revealing IGF2 Gene as a Diagnostic and Prognostic Biomarker2026
  2. 2Abstract 3635: Insulin-like growth factor receptor predicts poor prognosis in early-stage non-small cell lung cancer2024
  3. 3Prognostic and therapeutic relevance of IL2RG-related LncRNAs in clear cell renal cell carcinoma2025
  4. 4Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461’s Therapeutic Promise2024 · 2 citations
  5. 5IGF2BP2 Promotes Esophageal Squamous-Cell Carcinoma Progression with Potential Involvement of PI3K/AKT Signaling2026