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June 14, 2026CureusOpen Access

A Comprehensive Pan-Cancer Analysis Revealing IGF2 Gene as a Diagnostic and Prognostic Biomarker

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Authors

WAWala AbdallahAAAyman E AbbasAAAmal H. A Assed

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Overview

Comprehensive analysis identifies IGF2's diagnostic and prognostic potential in multiple cancers, suggesting clinical utility.

Key Points

  • The study aims to define the diagnostic and prognostic potential of the IGF2 gene across various cancers.
  • Utilized bioinformatic platforms such as TIMER, GEPIA, and cBioPortal to analyze IGF2 expression.
  • Conducted immune infiltration analysis to assess tumor-immune interactions involving IGF2.
  • Performed Kaplan-Meier survival analysis correlating IGF2 expression with overall survival across different types of cancer.
  • IGF2 was significantly upregulated in cholangiocarcinoma, liver hepatocellular carcinoma, kidney chromophobe, and stomach adenocarcinoma with P-values ranging from 1.43E-04 to 3.72E-05.
  • Elevated IGF2 expression correlated with good prognosis in kidney renal papillary cell carcinoma (P = 7.2E-05).
  • Immune infiltration analysis revealed correlations with macrophages and CD4+ T cells in stomach adenocarcinoma (P = 1.30E-10, 2.61E-06).

Cite This Study

Abdallah et al. (2026) studied this question.

synapsesocial.com/papers/6a2e456cb1cc60ccdea8a868https://doi.org/10.7759/cureus.110688
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Also Consider

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  1. 1High IGF2 expression is associated with poor clinical outcome in human ovarian cancer2015 · 39 citations
  2. 2IGF2BP2 Overexpression Predicts Poor Prognosis and Correlates with PD-L1 Expression in Intrahepatic Cholangiocarcinoma2026
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