Key result
High IGF2 expression is linked to ~44% worse overall survival in ovarian cancer patients.
Why the study?
IGF2 expression differences between cancerous and non-cancerous ovarian tissues and its prognostic significance in ovarian cancer patients were not fully characterized.
Is high IGF2 expression associated with poorer survival in ovarian cancer patients?
Population
1,648 ovarian cancer patients for survival analysis; 35 and 72 ovarian tissue samples for mRNA and protein analysis respectively
Comparison
High IGF2 expression vs low IGF2 expression or non-cancerous ovarian tissues
Design
Observational cohort study
Authors
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High IGF2 expression was associated with poorer ovarian cancer survival; supports prognostic biomarker research but should not yet change practice.
Observational (n=1,648)
Is high IGF2 expression associated with poorer survival in ovarian cancer patients?
Hazard Ratio: 1.44
p-value: p=0.000
High IGF2 expression is frequently increased in ovarian cancer tissues and serves as a significant prognostic factor for poor survival.
Dong et al. (2015) conducted an observational in Ovarian cancer (n=1,648). High IGF2 expression vs. Low IGF2 expression was evaluated on Overall survival (HR 1.44, p=0.000). High IGF2 expression is significantly associated with poorer overall survival in patients with ovarian cancer (HR 1.44, P=0.000).
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