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July 1, 1997The Journal of Clinical Endocrinology & Metabolism

Elevated Serum Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2) and Decreased IGFBP-3 in Epithelial Ovarian Cancer: Correlation with Cancer Antigen 125 and Tumor-Associated Trypsin Inhibitor

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Why the study?

Do serum levels of IGFBP-2 and IGFBP-3 correlate with tumor markers in patients with epithelial ovarian cancer?

Population

20 patients with epithelial ovarian cancer, 10 patients with benign ovarian tumors, and 8 healthy…

Design

Case-control

Authors

AFAllan FlyvbjergUniversity of Copenhagen

Discussion

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Overview

May support IGFBP-2 as adjunct marker in ovarian cancer; leaves open prospective validation before any clinical use.

Structured PICO

Do serum levels of IGFBP-2 and IGFBP-3 correlate with tumor markers in patients with epithelial ovarian cancer?

P
Population
20 patients with epithelial ovarian cancer, 10 patients with benign ovarian tumors, and 8 healthy age-matched controls (n=38)
C
Comparator
Benign ovarian tumors and healthy age-matched controls
O
Outcome
Serum levels of IGFBP-2 and IGFBP-3 and their correlation with tumor markers (CA 125 and tumor-associated trypsin inhibitor)surrogate

Serum IGFBP-2 levels are elevated in epithelial ovarian cancer and correlate with CA 125, suggesting potential utility as an additional tumor marker.

Cite This Study

Allan Flyvbjerg (1997) studied this question.

synapsesocial.com/papers/6a855a5502d378e0d14e209bhttps://doi.org/10.1210/jc.82.7.2308
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer.1994 · 95 citations
  2. 2Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion.2005 · 145 citations
  3. 3Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer2025
  4. 4Association of circulating insulin-like growth factor 1 and insulin-like growth factor binding protein 3 with the risk of ovarian cancer: A systematic review and meta-analysis2015 · 15 citations
  5. 5Circulating IGF system and treatment outcome in epithelial ovarian cancer2013 · 43 citations