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January 1, 2005Molecular CancerOpen Access

Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion.

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Population

Ovarian cancer cell lines and human ovarian tissue samples

Comparison

Overexpression of IGFBP2 and siRNA attenuation… vs Control cells

Design

Preclinical

Authors

ELEun‐Ju LeeCMCristian MirceanISIlya Shmulevich

Discussion

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Overview

Should not yet change ovarian cancer practice; hypothesis-generating for IGFBP2 as therapeutic target.

Structured PICO

P
Population
Ovarian cancer cell lines (SKOV3 and PA-1) and human ovarian tissue samples (normal, borderline serous tumors, invasive serous carcinomas)
I
Intervention
Overexpression of IGFBP2 (in SKOV3 cells) and siRNA attenuation of IGFBP2 (in PA-1 cells)
C
Comparator
Control cells (non-overexpressing SKOV3, non-attenuated PA-1)
O
Outcome
Cell invasion capacity measured by Matrigel invasion assaysurrogate

IGFBP2 enhances the invasion capacity of ovarian cancer cells, suggesting it may be a potential target for cancer therapy.

Cite This Study

Lee et al. (2005) studied this question.

synapsesocial.com/papers/6a83f89e6de9cd8ef3ee80f9https://doi.org/10.1186/1476-4598-4-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated Serum Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2) and Decreased IGFBP-3 in Epithelial Ovarian Cancer: Correlation with Cancer Antigen 125 and Tumor-Associated Trypsin Inhibitor1997 · 54 citations
  2. 2Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer.1994 · 95 citations
  3. 3IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis, decreased IGFBP-1 expression and increased tumorigenicity1998 · 51 citations
  4. 4High IGF2 expression is associated with poor clinical outcome in human ovarian cancer2015 · 39 citations
  5. 5Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer.2017 · 35 citations