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January 1, 2017Open Access

Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer.

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Population

Ovarian cancer (specifically epithelial ovarian cancer)

Design

Review

Authors

APAmutha PeriyasamyTRThangarajan Rajkumar

Discussion

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Overview

Hypothesis-generating for IGF1R inhibitors in ovarian cancer; prospective trials needed before clinical consideration.

Structured PICO

P
Population
Ovarian cancer (specifically epithelial ovarian cancer)
I
Intervention
IGF1R inhibitors and combination therapy

This review highlights the potential of targeting the insulin and IGF1 signaling pathways, particularly with IGF1R inhibitors, in the clinical management of ovarian cancer.

Cite This Study

Periyasamy et al. (2017) studied this question.

synapsesocial.com/papers/6a83f89e6de9cd8ef3ee80f2https://doi.org/10.4103/ijmpo.ijmpo_3_17
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion.2005 · 145 citations
  2. 2Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer.1994 · 95 citations
  3. 3Pregnancy‐associated plasma protein‐A (PAPP‐A) cleaves insulin‐like growth factor binding protein (IGFBP)‐5 independent of IGF: implications for the mechanism of IGFBP‐4 proteolysis by PAPP‐A2001 · 291 citations
  4. 4Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers2005 · 270 citations
  5. 5Correlation Analysis of HOX, ErbB and IGFBP Family Gene Expression in Ovarian Cancer2008 · 19 citations