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November 22, 2013Endocrine Related CancerOpen Access

Circulating IGF system and treatment outcome in epithelial ovarian cancer

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Why the study?

Do preoperative circulating IGF system components predict treatment outcome in patients with epithelial ovarian cancer?

Population

228 patients with epithelial ovarian cancer at two tertiary centers

Design

Cohort

Follow-up

median 44 months

Authors

YHYu-Fang HuangFujian Medical UniversityWCWen‐Fang ChengUniversity of California, San FranciscoYWYu-Peng Wu

Discussion

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Member takes

Overview

May support IGFBP2 as a prognostic marker in ovarian cancer; leaves open prospective validation before clinical use.

Structured PICO

Do preoperative circulating IGF system components predict treatment outcome in patients with epithelial ovarian cancer?

P
Population
228 patients with epithelial ovarian cancer at two tertiary centers
I
Intervention
Preoperative serum levels of total IGF1, IGF2, IGF-binding protein 2 (IGFBP2), and IGFBP3
O
Outcome
Mortality and cancer progression (overall and progression-free survival)hard clinical

Elevated serum IGFBP2 levels at diagnosis are an independent predictor of mortality in patients with epithelial ovarian cancer.

Cite This Study

Huang et al. (2013) studied this question.

synapsesocial.com/papers/6a83f89e6de9cd8ef3ee80f5https://doi.org/10.1530/erc-13-0274
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High IGF2 expression is associated with poor clinical outcome in human ovarian cancer2015 · 39 citations
  2. 2Elevated Serum Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2) and Decreased IGFBP-3 in Epithelial Ovarian Cancer: Correlation with Cancer Antigen 125 and Tumor-Associated Trypsin Inhibitor1997 · 54 citations
  3. 3Preoperative Level of Insulin-Like Growth Factor Binding Protein 2 Predicts The Suboptimal Outcome After Primary Debulking Surgery in Patients with Advance Ovarian Cancer2023 · 2 citations
  4. 4Clinical significance of differential plasma proteins levels in the diagnosis of epithelial ovarian cancer2025
  5. 5The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer2026