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February 25, 2015Molecular and Clinical OncologyOpen Access

Association of circulating insulin-like growth factor 1 and insulin-like growth factor binding protein 3 with the risk of ovarian cancer: A systematic review and meta-analysis

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Key result

High circulating levels of IGF-1 were not significantly associated with an increased risk of ovarian cancer compared to the lowest levels (OR 0.85).

Why the study?

Does the highest category of circulating IGF-1 or IGFBP-3 levels increase the risk of ovarian cancer compared to the lowest category?

Population

1,985 participants from 4 observational studies.

Comparison

Highest category of circulating IGF-1 or IGFBP-3… vs Lowest category of circulating IGF-1 or IGFBP-3…

Design

Meta-analysis

Authors

QWQiao WangTongji UniversityCBCe BianWeifang Medical UniversityHPHongling PengCentral South University

Discussion

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Overview

No association with IGF-1 does not support its use for ovarian cancer risk stratification; leaves open IGF axis contributions in carcinogenesis.

Study Design

Type

Meta-Analysis (n=1,958)

Structured PICO

Does the highest category of circulating IGF-1 or IGFBP-3 levels increase the risk of ovarian cancer compared to the lowest category?

P
Population
1,958 women (627 cases and 1,358 controls) from 4 observational studies evaluating the association between circulating IGF-1 and IGFBP-3 levels and ovarian cancer risk.
E
Exposure
Highest category of circulating IGF-1 or IGFBP-3 levels
C
Comparator
Lowest category of circulating IGF-1 or IGFBP-3 levels
O
Outcome
Risk of ovarian cancerhard clinical

Main Result

Odds Ratio: 0.85 (95% CI 0.51–1.4)

This meta-analysis found no significant association between circulating IGF-1 or IGFBP-3 levels and the risk of ovarian cancer.

Limitations

  • Small number of relevant studies and limited total sample size.
  • Majority of control groups were hospital-based, meaning controls were not definitely free of other benign diseases that may affect IGF levels.
  • Inclusion of females using exogenous hormones at blood donation contributed to significant heterogeneity.
  • Blood samples in the retrospective observational study were not obtained prior to the incidence of disease.
  • Small number of current relevant studies and sample size included
  • Controls were not definitely free of other benign diseases that may affect circulating levels of IGFs
  • Inability to solve all heterogeneity problems without sufficient relevant studies with available additional data on confounders

Cite This Study

Wang et al. (2015) conducted a meta-analysis in Ovarian cancer (n=1,958). High circulating insulin-like growth factor 1 (IGF-1) vs. Lowest circulating IGF-1 levels was evaluated on Ovarian cancer risk (highest vs lowest exposure levels) (OR 0.85, 95% CI 0.51-1.40). High circulating levels of IGF-1 were not significantly associated with an increased risk of ovarian cancer compared to the lowest levels (OR 0.85).

synapsesocial.com/papers/6a94d5a577c45f16fa0b16bchttps://doi.org/10.3892/mco.2015.516
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated Serum Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2) and Decreased IGFBP-3 in Epithelial Ovarian Cancer: Correlation with Cancer Antigen 125 and Tumor-Associated Trypsin Inhibitor1997 · 54 citations
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  3. 3Serum insulin-like growth factor-I and breast cancer2000 · 341 citations
  4. 4Meta-analysis of Observational Studies in Epidemiology A Proposal for Reporting2000 · 20,946 citations
  5. 5Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis1992 · 2,388 citations