What question did this study set out to answer?

To evaluate the observational association and determine the causal relationship between circulating insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3), and breast cancer risk.

March 10, 2020Annals of OncologyOpen Access

Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼430 000 women

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Authors

NMNeil MurphyJet Propulsion Laboratory AKAnika KnüppelUniversity College Lahore NPNikos PapadimitriouUniversity of Thessaly

Discussion

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Implication

Cohort and Mendelian randomization analyses reveal higher circulating IGF-1 increases breast cancer risk in women, suggesting interventions targeting this pathway may aid prevention.

Key Points

To evaluate the observational association and determine the causal relationship between circulating insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3), and breast cancer risk.
Prospective cohort analysis of 206,263 women in the UK Biobank followed for a median of 7.1 years, utilizing multivariable Cox proportional hazards models adjusted for regression dilution using repeat measures from 6,711 women.
Two-sample Mendelian randomization evaluating genetic variants associated with IGF-1 and IGFBP-3 against breast cancer risk using genome-wide association data from 122,977 cases and 105,974 controls.
UK Biobank observational analyses identified 4,360 incident breast cancer cases, showing higher IGF-1 was associated with increased breast cancer risk (HR per 5 nmol/L increment = 1.11, 95% CI = 1.07–1.16).
Genetically predicted IGF-1 was associated with increased breast cancer risk overall (OR per 5 nmol/L increment = 1.05, 95% CI = 1.01–1.10; P = 0.02) and in estrogen-positive tumors, but not in estrogen-negative tumors.
Genetically predicted IGFBP-3 concentrations were not associated with breast cancer risk (OR per 1-SD increment = 1.00, 95% CI = 0.97–1.04; P = 0.98).

Cite This Study

Murphy et al. (2020) studied this question.

synapsesocial.com/papers/6a81d72c5feb15765cbf6887 https://doi.org/10.1016/j.annonc.2020.01.066

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Implication

Cohort and Mendelian randomization analyses reveal higher circulating IGF-1 increases breast cancer risk in women, suggesting interventions targeting this pathway may aid prevention.

Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼430 000 women

Discussion

Member takes

Implication

Key Points

Cite This Study

Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼430 000 women

Discussion

Member takes

Implication

Key Points

Cite This Study

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