Circulating insulin-like growth factor-I and risk of 25 common conditions: outcome-wide analyses in the UK Biobank study

Figures

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  Fig. 1. Relative risk of 25 common conditions per 5 nmol/l higher IGF-I concentration in UK Biobank, corrected for regression dilution bias. Stratified for age group (< 45, 45–49, 50–54, 55–59, 60–64, and ≥ 65 years), sex and region and adjusted for age (underlying time variable), ethnicity (White, non-white, unknown), deprivation (Townsend index quintiles, unknown), qualification (College or university degree/vocational qualification, National examination at ages 17–18,National examination at age 16, other or unknown), smoking (never, former, current < 15 cigarettes/day, current > 15 cigarettes/ day, unknown), physical activity (< 10, 10– < 20, 20–40, 40- < 60, > = 60 MET hours per week, unknown), alcohol intake (< 1.0, 1.0–4.9, 5.0–9.9, 10.0–14.9, 15.0–19.9, 20.0–24.9, and ≥ 25.0 g/day, non-drinker, and unknown), height (continuous), and in women: menopausal status (pre-, postmenopausal, unknown), hormone-replacement therapy (never, past, current, unknown), oral contraceptive pill intake (never, past, current, unknown), parity (nulliparous, 1–2, 3 or more, unknown), and body mass index (< 20.0, 20.0–22.49, 22.5–24.99, 25.0–27.49, 27.5–29.99, 30.0–32.49, 32.5–34.99, > 35.0). CI…

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  Fig. 2. Relative risk of 25 common conditions per 5 nmol/l higher IGF-I concentration by follow-up time at diagnosis. Stratified for age group (< 45, 45–49, 50–54, 55–59, 60–64, and ≥ 65 years), sex and region and adjusted for age (underlying time variable), ethnicity (White, non-white, unknown), deprivation (Townsend index quintiles, unknown), qualification (College or university degree/vocational qualification, National examination at ages 17–18,National examination at age 16, other or unknown), smoking (never, former, current < 15 cigarettes/day, current > 15 cigarettes/ day, unknown), physical activity (< 10, 10- < 20, 20–40, 40- < 60, > = 60 MET hours per week, unknown), alcohol intake (< 1.0, 1.0–4.9, 5.0–9.9, 10.0–14.9, 15.0–19.9, 20.0–24.9, and ≥ 25.0 g/day, non-drinker, and unknown), height (continuous), and in women: menopausal status (pre-, postmenopausal, unknown), hormone-replacement therapy (never, past, current, unknown), oral contraceptive pill intake (never, past, current, unknown), parity (nulliparous, 1–2, 3 or more, unknown), and body mass index (< 20.0, 20.0–22.49, 22.5–24.99, 25.0–27.49, 27.5–29.99, 30.0–32.49, 32.5–34.99, > 35.0). GERD Gastro-oesophageal reflux…