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July 26, 2026Blood AdvancesOpen Access

Clinical utility of real-time comprehensive molecular testing in large B-cell lymphoma

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Authors

DCDai ChiharaKBKumudha BalakrishnanGMGita Masand

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Overview

Pilot study shows quick comprehensive profiling improves treatment decisions in large B-cell lymphoma.

Key Points

  • This study aims to evaluate the feasibility and turnaround time of comprehensive molecular testing for large B-cell lymphoma.
  • Pilot study with 100 patients aged ≥18 with large B-cell lymphoma (NCT05464823).
  • Utilized whole exome sequencing, RNA-seq, and copy number analysis on formalin-fixed paraffin-embedded tissues.
  • Median turnaround time for reports was 8 days, with 73% of reports delivered in ≤10 days.
  • 71 out of 100 patient samples passed quality control for analysis.
  • High-risk event-free survival signature correlated with dark zone signature and lymphoma microenvironment.
  • Study supports integration of molecular profiling for clinical decision-making and future clinical trials.

Cite This Study

Chihara et al. (2026) studied this question.

synapsesocial.com/papers/6a65a76fd3aea3239cd783behttps://doi.org/10.1182/bloodadvances.2025019468
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