Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury*

Romeen Lavani; Wei‐Tien Chang; Travis Anderson; Zuo‐Hui Shao; Kimberly R. Wojcik; Changqing Li; Robert F. Pietrowski; David G. Beiser; Ahamed H. Idris; Kimm J. Hamann; Lance B. Becker; Terry L. Vanden Hoek

doi:10.1097/01.ccm.0000269209.53450.ec

May 23, 2007Critical Care Medicine

Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury*

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Key Points

This research aims to assess how changes in CO2 levels during reperfusion influence mitochondrial oxidant injury in ischemic cardiomyocytes.
Embryonic chick cardiomyocytes subjected to simulated ischemia followed by varying CO2 reperfusion conditions.
Cell viability measured via propidium iodide; oxidant generation monitored using reactive oxygen species and nitric oxide assays.
Comparisons made between normocarbic, hypercarbic, and hypocarbic reperfusion conditions.
Hypercarbic reperfusion reduced cell death from 54.8% to 26.3% (p < .001) and decreased reactive oxygen species (p < .05).
Hypocarbic reperfusion increased cell death to 80.4% (p < .01) and nearly doubled reactive oxygen species levels (p = .052).
NO synthase inhibition restored cell death to 54.3% in hypercarbic conditions (p < .05) and reduced protective effects, while mitochondrial inhibition during reperfusion decreased cell death from 85.9% to 52.2% (p < .01).

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Implication

Comparative laboratory investigation reveals that CO2 levels during reperfusion affect cardiomyocyte injury, indicating potential therapeutic strategies.

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Lavani et al. (2007) studied this question.

synapsesocial.com/papers/6a65a8cbeb7a5bf67ec4dd95 https://doi.org/10.1097/01.ccm.0000269209.53450.ec

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Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury*

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury*

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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