What is the clinical evidence from this study?

Study design: Other. Population: Myocardial stunning (n=31). Intervention: Staged reperfusion vs. Control reperfusion. Primary outcome: Fractional shortening.

What question did this study set out to answer?

This study aims to investigate the effects of staged reperfusion on myocardial stunning and the role of transient acidosis.

November 1, 1991Circulation

Staged reperfusion attenuates myocardial stunning in dogs. Role of transient acidosis during early reperfusion.

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Key result

Staged reperfusion significantly improved fractional shortening and attenuated myocardial stunning in dogs, an effect mediated by transient acidosis during early reperfusion.

Why the study?

Does staged reperfusion attenuate myocardial stunning in dogs after coronary occlusion?

Population

31 dogs subjected to 15 minutes of coronary artery occlusion

Comparison

Staged reperfusion vs Control reperfusion

Design

Preclinical

Follow-up

3 hours

Authors

MHM HoriOsaka International Cancer Institute MKMasafumi KitakazeHeart Failure & Transplant HSHideyuki SatoUniversity of Shizuoka

Discussion

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Implication

Staged reperfusion improved postischemic contractility in dogs; leaves open translation to clinical reperfusion protocols.

Key Points

This study aims to investigate the effects of staged reperfusion on myocardial stunning and the role of transient acidosis.
31 dogs were tested with staged reperfusion following 15 minutes of coronary artery occlusion.
Acidosis was induced during reperfusion and effects on contractile function were measured.
Intracoronary infusions of sodium bicarbonate and hydrogen chloride were used to assess pH changes.
Contractile dysfunction was observed 3 hours after reperfusion in control group.
Staged reperfusion led to significantly improved fractional shortening and lower venous blood pH.
Infusion of sodium bicarbonate abolished the benefits of staged reperfusion, while hydrogen chloride infusion mimicked pH changes and attenuated myocardial stunning.

Structured PICO

Does staged reperfusion attenuate myocardial stunning in dogs after coronary occlusion?

Population

31 dogs subjected to 15 minutes of coronary artery occlusion followed by reperfusion to evaluate myocardial stunning.

Intervention

Staged reperfusion

Comparator

Control reperfusion

Outcome

Myocardial stunning (measured by fractional shortening) 3 hours after onset of reperfusionsurrogate

Transient acidosis during staged reperfusion attenuates myocardial stunning in a canine model of ischemia-reperfusion.

Cite This Study

Hori et al. (1991) studied Myocardial stunning (n=31). Staged reperfusion vs. Control reperfusion was evaluated on Fractional shortening. Staged reperfusion significantly improved fractional shortening and attenuated myocardial stunning in dogs, an effect mediated by transient acidosis during early reperfusion.

synapsesocial.com/papers/6a65a8d4eb7a5bf67ec4ddaa https://doi.org/10.1161/01.cir.84.5.2135

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Staged reperfusion attenuates myocardial stunning in dogs. Role of transient acidosis during early reperfusion.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Staged reperfusion attenuates myocardial stunning in dogs. Role of transient acidosis during early reperfusion.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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