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July 26, 2026BiomoleculesOpen Access

The Promise and Pursuit of MicroRNAs for Cancer Treatment

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Authors

CBCamaleta BootheARArianna RossiJKJenniffer Kalil

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Overview

Review explores microRNA mimics' efficacy in cancer therapy, highlighting their potential and challenges.

Key Points

  • This review aims to evaluate the role of microRNAs and their mimics in cancer therapy and drug resistance.
  • Analyzed the development and successful use of microRNA mimics in various settings (in vitro, in vivo, clinical trials).
  • Examined how chemical modifications enhance the stability and therapeutic potential of microRNA mimics.
  • Discussed the importance of delivery vehicles and the challenges they pose in clinical applications.
  • MicroRNA mimics can control cancer-related processes such as metastasis, apoptosis, and proliferation.
  • Modifications improve the stability and effectiveness of microRNA therapies against drug resistance.
  • Findings from the siRNA therapeutic Patisiran provide insights for advancing microRNA applications.

Cite This Study

Boothe et al. (2026) studied this question.

synapsesocial.com/papers/6a65a91fd3aea3239cd792c1https://doi.org/10.3390/biom16081086
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  1. 1Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives2023 · 57 citations
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