Key result
In healthy mouse hearts, the right and left ventricles differ in the degree of orientational disorder of actin within filaments and in the kinetics of the cross-bridge cycle during contraction.
Population
Healthy mouse hearts (ex vivo ventricular myofibrils)
Comparison
Right ventricle (RV) myofibrils vs Left ventricle (LV) myofibrils
Design
Preclinical
Authors
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Challenges assumption of uniform ventricular myocardium in mice; leaves open relevance to human physiology or disease.
Healthy mouse right and left ventricles exhibit distinct mesoscopic differences in actin orientation and myosin cross-bridge kinetics, challenging the assumption that ventricular muscles are identical.
Nagwekar et al. (2014) studied Healthy mouse hearts. Right ventricle vs. Left ventricle was evaluated on Orientational disorder of actin within filaments and kinetics of the cross-bridge cycle. In healthy mouse hearts, the right and left ventricles differ in the degree of orientational disorder of actin within filaments and in the kinetics of the cross-bridge cycle during contraction.
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