Key result
Female sex was associated with a higher proportion of echocardiographic responders to cardiac resynchronization therapy at 12 months compared to male sex (76.1% vs 59.3%, P<0.05).
Why the study?
Does female sex influence the left ventricular remodeling response in heart failure patients treated with cardiac resynchronization therapy?
Population
195 heart failure patients who underwent CRT and completed 6 and 12-month clinical and echocardiographic…
Comparison
Cardiac resynchronization therapy (CRT) vs Male patients receiving CRT
Design
Cohort
Follow-up
12 months
Authors
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Women may experience greater CRT response in HF; leaves open sex-specific device selection pending confirmation.
Cohort (n=334)
Does female sex influence the left ventricular remodeling response in heart failure patients treated with cardiac resynchronization therapy?
Absolute Event Rate: 76.1% vs 59.3%
p-value: p=<0.05
Female sex is independently associated with a greater reduction in left ventricular volumes and a higher rate of echocardiographic response to CRT compared to men.
Lilli et al. (2007) conducted a cohort in Heart failure (n=334). Female sex vs. Male sex was evaluated on Echocardiographic response (LV end-systolic volume reduction by at least 10%) at 12 months (p=<0.05). Female sex was associated with a higher proportion of echocardiographic responders to cardiac resynchronization therapy at 12 months compared to male sex (76.1% vs 59.3%, P<0.05).
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