What is the clinical evidence from this study?

Study design: Case Report. Population: Idiopathic hypereosinophilic syndrome (n=1). Intervention: High-dose corticosteroids, vitamin K antagonist, and diuretics. Primary outcome: Diagnosis and initial management.

What does this research mean for the field?

Multimodality cardiovascular imaging can accurately characterize isolated right ventricular eosinophilic endomyocardial fibrosis and associated intracavitary thrombus in idiopathic hypereosinophilic syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the clinical presentation, multimodality imaging assessment, and therapeutic management of isolated right ventricular endomyocardial fibrosis caused by idiopathic hypereosinophilic syndrome.

July 27, 2026CureusOpen Access

Idiopathic Hypereosinophilic Syndrome Presenting as Isolated Right Ventricular Endomyocardial Fibrosis With Intracavitary Thrombus: A Multimodality Imaging Case Report

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Key result

Multimodality imaging detects isolated right ventricular endomyocardial fibrosis and thrombus in idiopathic hypereosinophilic syndrome.

Why the study?

Isolated right ventricular endomyocardial fibrosis in idiopathic hypereosinophilic syndrome is exceptionally uncommon and can mimic other intracardiac pathologies, making diagnosis challenging.

Population

One 55-year-old man presenting with progressive bilateral lower-limb edema

Design

Case report

Authors

NLNadia LoudiyiMilitary Hospital MMMohamed Malki HEHafsa ErreguiMohammed V University

Discussion

Member takes

Implication

May support multimodality imaging in suspected cases; leaves open broader validation in hypereosinophilic syndrome.

Key Points

To describe the clinical presentation, multimodality imaging assessment, and therapeutic management of isolated right ventricular endomyocardial fibrosis caused by idiopathic hypereosinophilic syndrome.
Evaluated a 55-year-old man presenting with bilateral lower-limb edema using transthoracic echocardiography, cardiac magnetic resonance, and thoracic CT (N=1).
Conducted extensive laboratory, bone marrow, and molecular analyses (including FIP1L1-PDGFRA, PDGFRB, FGFR1, JAK2, CALR, MPL, and BCR::ABL1) to rule out secondary and clonal causes.
Laboratory testing identified severe hypereosinophilia (eosinophils 9.0 × 10⁹/L) alongside elevated high-sensitivity cardiac troponin (284 ng/L) and NT-proBNP (3,000 pg/mL).
Multimodality imaging revealed right ventricular apical obliteration, diffuse subendocardial late gadolinium enhancement indicating fibrosis, and an avascular intracavitary thrombus.
Comprehensive infectious, autoimmune, and oncologic screens were negative, confirming idiopathic hypereosinophilic syndrome successfully treated with high-dose corticosteroids, anticoagulation, and diuretics.

Study Design

Type

Case Report (n=1)

Multicenter

Structured PICO

Population

A 55-year-old man presenting with progressive bilateral lower-limb edema diagnosed with idiopathic hypereosinophilic syndrome and isolated right ventricular endomyocardial fibrosis.

Intervention

High-dose corticosteroids (oral prednisone 1 mg/kg/day), vitamin K antagonist anticoagulation, and intravenous furosemide.

Multimodality imaging is crucial for diagnosing and characterizing isolated right ventricular endomyocardial fibrosis and intracavitary thrombus in patients with idiopathic hypereosinophilic syndrome.

Limitations

Treatment had only recently been initiated, precluding assessment of the clinical response or long-term outcome.
Short follow-up precluding assessment of clinical response or long-term outcome

Cite This Study

Loudiyi et al. (2026) conducted a case report in Idiopathic hypereosinophilic syndrome (n=1). High-dose corticosteroids, vitamin K antagonist, and diuretics was evaluated on Diagnosis and initial management. Multimodality cardiovascular imaging successfully identified isolated right ventricular endomyocardial fibrosis and intracavitary thrombus in a 55-year-old man with idiopathic hypereosinophilic syndrome.

synapsesocial.com/papers/6a67009540bca442e0d4a6c9 https://doi.org/10.7759/cureus.113350

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Idiopathic Hypereosinophilic Syndrome Presenting as Isolated Right Ventricular Endomyocardial Fibrosis With Intracavitary Thrombus: A Multimodality Imaging Case Report

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Idiopathic Hypereosinophilic Syndrome Presenting as Isolated Right Ventricular Endomyocardial Fibrosis With Intracavitary Thrombus: A Multimodality Imaging Case Report

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

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