Relations of Central Hemodynamics and Aortic Stiffness with Left Ventricular Structure and Function: The Framingham Heart Study
Key result
Central hemodynamics and aortic stiffness were variably related to LV structure, with mean arterial pressure positively associated with LV wall thickness (r=0.168; P<0.0001).
Population
5799 participants of the Framingham Heart Study, mean age 51 years, 54% women
Design
Cohort
Authors
Discussion
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Member takes
Implication
Pulsatile vs steady hemodynamics show distinct LV relations; leaves open whether targeting central pulse pressure alters remodeling or outcomes.
Study Design
Type
Cross-Sectional (n=5,799)
Structured PICO
P
Population
5,799 participants of the Framingham Heart Study (mean age 51 years, 54% women) assessed for the relationship between central hemodynamics, aortic stiffness, and left ventricular structure and function.
O
Outcome
Echocardiographic left ventricular (LV) dimensions and systolic and diastolic functionsurrogate
Main Result
Effect estimate: r=0.168
p-value: p=<0.0001
Pulsatile and steady components of central pressure, along with aortic stiffness, have distinct and variable associations with left ventricular structure and diastolic function.
Cite This Study
Kaess et al. (2016) reported a cross-sectional. Central hemodynamics and aortic stiffness was evaluated on Left ventricular wall thickness (r=0.168, p=<0.0001). Central hemodynamics and aortic stiffness were variably related to LV structure, with mean arterial pressure positively associated with LV wall thickness (r=0.168; P<0.0001).