Key result
Greater aortic stiffness linked to ~29% higher incident heart failure risk per SD.
Why the study?
Does greater central arterial stiffness increase the risk of incident heart failure in middle-aged to elderly individuals without clinical HF?
Population
2,539 Framingham Study participants without clinical HF, mean age 64 years, 56% women.
Comparison
Higher central arterial stiffness vs Lower central arterial stiffness
Design
Cohort
Follow-up
10.1 (range 0.04–12.9) years
Authors
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Supports aortic stiffness as HF risk marker in community cohorts; leaves open causal role and intervention targets.
Cohort (n=2,539)
Does greater central arterial stiffness increase the risk of incident heart failure in middle-aged to elderly individuals without clinical HF?
Effect estimate: HR 1.29 per SDU (95% CI 1.02-1.64)
p-value: p=0.037
Greater central aortic stiffness is independently associated with an increased risk of incident heart failure in a community-based population.
Tsao et al. (2015) conducted a cohort in Incident heart failure (n=2,539). Central arterial stiffness (iCFPWV) was evaluated on Incident heart failure (HR 1.29 per SDU, 95% CI 1.02-1.64, p=0.037). Greater aortic stiffness was associated with an increased risk of incident heart failure (HR 1.29 per SD unit; 95% CI 1.02-1.64; P=0.037) over a 10.1-year follow-up.
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