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July 29, 2026Microbiology SpectrumOpen Access

Biofilm, virulence, and ESBL-mediated resistance: unmasking Klebsiella spp. UTIs

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Authors

MSMaisha SamioBPBushra Bente Rahman PraptiKAKazi Mohimen Alam Arnop

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Overview

Randomized trial investigates virulence and resistance in Klebsiella spp. UTIs, highlighting risks in treatment.

Key Points

  • This research examines the prevalence of genetic factors linked to virulence and drug resistance in Klebsiella spp. causing UTIs.
  • Collected 718 midstream urine samples from patients for analysis.
  • Identified bacterial isolates using cultural, biochemical assays, and PCR techniques.
  • Assessed biofilm formation with Congo red agar and microtiter plate assays.
  • 95% of isolates were multidrug resistant (MDR); 3 were extremely drug resistant (XDR).
  • Predominant ESBL genes were bla SHV (50%) and bla TEM (40%).
  • Moderate to strong biofilm producers exhibited significantly higher resistance (P < 0.05).

Cite This Study

Samio et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2d4c8da07d9defa6c54https://doi.org/10.1128/spectrum.00664-26
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