Key result
Spontaneously hypertensive rats had significantly elevated mean circulatory filling pressure compared to normotensive rats at 4-6 weeks (6.6 vs 5.4 mm Hg), indicating increased venous tone.
Population
Male spontaneously hypertensive rats and normotensive Wistar-Kyoto rats at 4 to 6 and 8 to 10 weeks of age
Comparison
Ganglionic blockade with chlorisondamine vs Normotensive Wistar-Kyoto rats and baseline…
Design
Preclinical
Authors
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Does not alter clinical practice; leaves open venous tone as a hypertension mechanism in humans.
Absolute Event Rate: 6.6% vs 5.4%
Venous tone is increased via autonomic effector systems during the developmental stages of spontaneous hypertension in rats.
Martin et al. (1998) studied Spontaneous hypertension. Spontaneous hypertension (SHR strain) vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Mean circulatory filling pressure (MCFP) at 4 to 6 weeks of age. Spontaneously hypertensive rats had significantly elevated mean circulatory filling pressure compared to normotensive rats at 4-6 weeks (6.6 vs 5.4 mm Hg), indicating increased venous tone.
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