Why the study?
Does oral administration of digitoxin in a murine model achieve comparable serum levels and positive inotropic effects compared to subcutaneous administration and controls?
Does oral administration of digitoxin in a murine model achieve comparable serum levels and positive inotropic effects compared to subcutaneous administration and controls?
Oral administration of digitoxin in rats provides an inexpensive and effective model that achieves comparable serum levels to subcutaneous administration and demonstrates expected positive inotropic effects.
Supports oral digitoxin inotropy in rat models; leaves open translation to human HF therapy.
A novel inexpensive murine model of oral administration of digitoxin (100 micro g/kg per day) added to routine chow is described. Serum digitoxin levels achieved after oral (n = 5; 116 +/- 14 ng/mL) and subcutaneous (n = 5; 124 +/- 11 ng/mL) administration were similar. A significant increase in the maximal left ventricular pressure rise of treated (n = 9) compared with control (n = 6) rats (dP/dt: 8956 +/- 233 vs 7980 +/- 234 mmHg/s, respectively; P = 0.01) characterized the positive inotropic action of digitoxin. In addition, no differences were observed in treated compared with control rats with regard to the electrocardiogram and systolic and diastolic left ventricular pressures.
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Helber et al. (2004) studied Chronic digitalization (n=15). Oral digitoxin vs. Control was evaluated on Maximal left ventricular pressure rise (dP/dt) (p=0.01).
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