May 1, 1990Diabetic Medicine
Intramuscular Versus Subcutaneous Injection of Unmodified Insulin: Consequences for Blood Glucose Control in Patients with Type 1 Diabetes Mellitus
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Discussion
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Implication
Randomized trial compares intramuscular and subcutaneous insulin effects on blood glucose control in Type 1 diabetes, suggesting intramuscular may be beneficial.
Key Points
- The study aims to re-evaluate insulin absorption kinetics from intramuscular versus subcutaneous injection sites and their effects on blood glucose control in Type 1 diabetes.
- Guided by ultrasound, insulin absorption was measured for intramuscular (IM) and subcutaneous (SC) injections in lean Type 1 diabetic patients.
- T50% values were calculated during rest and different physical activity levels for both injection types over a 3-day period.
- Blood glucose levels and insulin profiles were compared after IM and SC injections before meals.
- IM injection showed faster absorption rates: T50% 232 min compared to 338 min for SC during rest (p<0.01).
- IM administration yielded lower blood glucose concentration variation (33% vs 43% for SC, p<0.01).
- No significant difference in hypoglycemic events or pain levels between IM and SC injection was reported.
Cite This Study
Vaag et al. (1990) studied this question.