What question did this study set out to answer?

This research aims to compare insulin absorption rates and hypoglycemia risk between intramuscular and subcutaneous injections during exercise in IDDM patients.

May 1, 1990Diabetes Care

Hypoglycemia Risk During Exercise After Intramuscular Injection of Insulin in Thigh in IDDM

Q: What is the clinical evidence from this study?

Study design: Other. Population: Insulin-dependent diabetes mellitus (IDDM) (n=10). Intervention: Intramuscular injection of insulin in the thigh vs. Subcutaneous injection of insulin in the thigh. Primary outcome: Rate constant for 125I-insulin during exercise (%/min) (p=<0.001).

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Key result

Intramuscular injection of insulin in the thigh followed by bicycle exercise significantly increased insulin absorption to 1.17 %/min (P<0.001) compared to subcutaneous injection.

Why the study?

Does intramuscular injection of insulin compared to subcutaneous injection increase insulin absorption and decrease plasma glucose during exercise in IDDM patients?

Population

10 patients with insulin-dependent diabetes mellitus (IDDM)

Comparison

Intramuscular injection of 125I-labeled… vs Subcutaneous injection of 125I-labeled…

Design

Other

Follow-up

40 min exercise plus 80-min recovery period

Authors

AFAnders FridUniversity of Victoria JÖJan ÖstmanKarolinska University Hospital BLBirgitta LindeSödertälje Sjukhus

Discussion

Member takes

Implication

Should not yet change practice for insulin delivery in exercising type 1 diabetes; hypothesis-generating for site-specific absorption.

Key Points

This research aims to compare insulin absorption rates and hypoglycemia risk between intramuscular and subcutaneous injections during exercise in IDDM patients.
Ten IDDM patients participated in a crossover design, receiving both intramuscular and subcutaneous insulin injections on consecutive days.
Insulin absorption was measured using radioactivity monitoring and plasma free immunoreactive insulin levels, while muscle and adipose blood flow were assessed with the 133Xe technique.
Plasma glucose levels were monitored intermittently during the exercise protocol.
Intramuscular injection of insulin led to a significant increase in absorption rate (0.46 to 1.17%/min, P<0.001) compared to subcutaneous injection (0.31 to 0.45%/min, NS).
Peak plasma free-IRI was 39 mU/L higher after intramuscular injection, with an approximate 80% greater area under the IRI curve.
Plasma glucose decreased approximately 2 mM more after intramuscular injection during exercise.

Structured PICO

Does intramuscular injection of insulin compared to subcutaneous injection increase insulin absorption and decrease plasma glucose during exercise in IDDM patients?

Population

10 patients with insulin-dependent diabetes mellitus studied on 2 consecutive days to compare intramuscular versus subcutaneous insulin injection during exercise.

Intervention

Intramuscular injection of 125I-labeled fast-acting insulin (10 U) in the thigh followed by bicycle exercise (60% of W170; 40 min)

Comparator

Subcutaneous injection of 125I-labeled fast-acting insulin (10 U) in the thigh followed by bicycle exercise (60% of W170; 40 min)

Outcome

Insulin absorption measured as disappearance of radioactivity (1st-order elimination rate constants) and appearance of plasma free immunoreactive insulin (IRI)surrogate

Main Result

Absolute Event Rate: 1.17% vs 0.45%

p-value: p=<0.001

Intramuscular injection of insulin in the thigh followed by exercise markedly increases insulin absorption and causes a substantial fall in plasma glucose compared to subcutaneous injection.

Cite This Study

Frid et al. (1990) studied Insulin-dependent diabetes mellitus (IDDM) (n=10). Intramuscular injection of insulin in the thigh vs. Subcutaneous injection of insulin in the thigh was evaluated on Rate constant for 125I-insulin during exercise (%/min) (p=<0.001). Intramuscular injection of insulin in the thigh followed by bicycle exercise significantly increased insulin absorption to 1.17 %/min (P<0.001) compared to subcutaneous injection.

synapsesocial.com/papers/6a6a04cd4a1baf0ffbe841ca https://doi.org/10.2337/diacare.13.5.473

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May 1, 1990Diabetes Care

Hypoglycemia Risk During Exercise After Intramuscular Injection of Insulin in Thigh in IDDM

View Full Paper

Ask AI

Bookmark

Key result

Intramuscular injection of insulin in the thigh followed by bicycle exercise significantly increased insulin absorption to 1.17 %/min (P<0.001) compared to subcutaneous injection.

Why the study?

Does intramuscular injection of insulin compared to subcutaneous injection increase insulin absorption and decrease plasma glucose during exercise in IDDM patients?

Population

10 patients with insulin-dependent diabetes mellitus (IDDM)

Comparison

Intramuscular injection of 125I-labeled… vs Subcutaneous injection of 125I-labeled…

Design

Other

Follow-up

40 min exercise plus 80-min recovery period

Authors

AFAnders FridUniversity of Victoria JÖJan ÖstmanKarolinska University Hospital BLBirgitta LindeSödertälje Sjukhus

Discussion

Member takes

Implication

Should not yet change practice for insulin delivery in exercising type 1 diabetes; hypothesis-generating for site-specific absorption.

Key Points

This research aims to compare insulin absorption rates and hypoglycemia risk between intramuscular and subcutaneous injections during exercise in IDDM patients.
Ten IDDM patients participated in a crossover design, receiving both intramuscular and subcutaneous insulin injections on consecutive days.
Insulin absorption was measured using radioactivity monitoring and plasma free immunoreactive insulin levels, while muscle and adipose blood flow were assessed with the 133Xe technique.
Plasma glucose levels were monitored intermittently during the exercise protocol.
Intramuscular injection of insulin led to a significant increase in absorption rate (0.46 to 1.17%/min, P<0.001) compared to subcutaneous injection (0.31 to 0.45%/min, NS).
Peak plasma free-IRI was 39 mU/L higher after intramuscular injection, with an approximate 80% greater area under the IRI curve.
Plasma glucose decreased approximately 2 mM more after intramuscular injection during exercise.

Structured PICO

Does intramuscular injection of insulin compared to subcutaneous injection increase insulin absorption and decrease plasma glucose during exercise in IDDM patients?

Population

10 patients with insulin-dependent diabetes mellitus studied on 2 consecutive days to compare intramuscular versus subcutaneous insulin injection during exercise.

Intervention

Intramuscular injection of 125I-labeled fast-acting insulin (10 U) in the thigh followed by bicycle exercise (60% of W170; 40 min)

Comparator

Subcutaneous injection of 125I-labeled fast-acting insulin (10 U) in the thigh followed by bicycle exercise (60% of W170; 40 min)

Outcome

Insulin absorption measured as disappearance of radioactivity (1st-order elimination rate constants) and appearance of plasma free immunoreactive insulin (IRI)surrogate

Main Result

Absolute Event Rate: 1.17% vs 0.45%

p-value: p=<0.001

Intramuscular injection of insulin in the thigh followed by exercise markedly increases insulin absorption and causes a substantial fall in plasma glucose compared to subcutaneous injection.

Cite This Study

synapsesocial.com/papers/6a6a04cd4a1baf0ffbe841ca https://doi.org/10.2337/diacare.13.5.473

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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