What question did this study set out to answer?

This research aims to determine if leg exercise affects the absorption of exogenous insulin in insulin-treated diabetics and its relation to glycemic responses.

December 1, 1979Diabetes

Exercise-induced Fall of Blood Glucose in Insulin-treated Diabetics Unrelated to Alteration of Insulin Mobilization

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Why the study?

Does leg exercise accelerate the absorption of exogenous insulin and alter the glycemic response in insulin-treated diabetics?

Population

9 insulin-dependent diabetics and 4 normal subjects

Comparison

20 U regular insulin injected into the arm or… vs Normal subjects during rest and exercise

Design

Other

Follow-up

During and immediately post-exercise

Authors

FKF. W. KemmerUniversity of Geneva PBPeter BerchtoldWorld Economic Forum MBMichael BergerGerman Primate Center

Discussion

Member takes

Implication

May not support site rotation to avert exercise hypoglycemia in insulin-treated diabetes; leaves open mechanisms of fixed hyperinsulinemia.

Key Points

This research aims to determine if leg exercise affects the absorption of exogenous insulin in insulin-treated diabetics and its relation to glycemic responses.
Studied nine insulin-dependent diabetics and four normal subjects during rest and exercise.
Insulin administered before exercise; monitored blood glucose and plasma insulin levels.
Measured changes in blood ketone bodies and lactate levels during exercise.
Blood glucose decreased by 15% immediately and by 50% after 30 minutes of exercise in diabetics.
Insulin levels did not significantly change during exercise; insulin absorption was unaffected by leg movement.
Normal subjects showed no disturbance in glucose homeostasis during exercise compared to diabetics.

Structured PICO

Does leg exercise accelerate the absorption of exogenous insulin and alter the glycemic response in insulin-treated diabetics?

Population

9 insulin-dependent diabetics and 4 normal subjects

Intervention

20 U regular insulin (labeled with 125I or unlabeled) injected into the arm or the leg, followed 35 min later by exercise (90 ± 10 W) for three consecutive 10-min periods

Comparator

Normal subjects during rest and exercise (no insulin injected)

Outcome

Absorption of exogenous insulin from its subcutaneous depot (measured by disappearance of 125I-radiation) and glycemic response to exercisesurrogate

Exercise-induced hypoglycemia in insulin-treated diabetics is likely due to a fixed hyperinsulinemic state rather than accelerated mobilization of insulin from the injection site, suggesting that changing the injection site to a nonmoving body part may not prevent it.

Limitations

Investigated only a specific situation

Cite This Study

Kemmer et al. (1979) studied this question.

synapsesocial.com/papers/6a75067af1e99ff85ab1d5cd https://doi.org/10.2337/diab.28.12.1131

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December 1, 1979Diabetes

Exercise-induced Fall of Blood Glucose in Insulin-treated Diabetics Unrelated to Alteration of Insulin Mobilization

View Full Paper

Ask AI

Bookmark

Why the study?

Does leg exercise accelerate the absorption of exogenous insulin and alter the glycemic response in insulin-treated diabetics?

Population

9 insulin-dependent diabetics and 4 normal subjects

Comparison

20 U regular insulin injected into the arm or… vs Normal subjects during rest and exercise

Design

Other

Follow-up

During and immediately post-exercise

Authors

FKF. W. KemmerUniversity of Geneva PBPeter BerchtoldWorld Economic Forum MBMichael BergerGerman Primate Center

Discussion

Member takes

Implication

May not support site rotation to avert exercise hypoglycemia in insulin-treated diabetes; leaves open mechanisms of fixed hyperinsulinemia.

Key Points

This research aims to determine if leg exercise affects the absorption of exogenous insulin in insulin-treated diabetics and its relation to glycemic responses.
Studied nine insulin-dependent diabetics and four normal subjects during rest and exercise.
Insulin administered before exercise; monitored blood glucose and plasma insulin levels.
Measured changes in blood ketone bodies and lactate levels during exercise.
Blood glucose decreased by 15% immediately and by 50% after 30 minutes of exercise in diabetics.
Insulin levels did not significantly change during exercise; insulin absorption was unaffected by leg movement.
Normal subjects showed no disturbance in glucose homeostasis during exercise compared to diabetics.

Structured PICO

Does leg exercise accelerate the absorption of exogenous insulin and alter the glycemic response in insulin-treated diabetics?

Population

9 insulin-dependent diabetics and 4 normal subjects

Intervention

20 U regular insulin (labeled with 125I or unlabeled) injected into the arm or the leg, followed 35 min later by exercise (90 ± 10 W) for three consecutive 10-min periods

Comparator

Normal subjects during rest and exercise (no insulin injected)

Outcome

Absorption of exogenous insulin from its subcutaneous depot (measured by disappearance of 125I-radiation) and glycemic response to exercisesurrogate

Limitations

Investigated only a specific situation

Cite This Study

Kemmer et al. (1979) studied this question.

synapsesocial.com/papers/6a75067af1e99ff85ab1d5cd https://doi.org/10.2337/diab.28.12.1131

Also Consider

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