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May 1, 1994AJP Endocrinology and Metabolism

Exercise-induced fall in insulin: mechanism of action at the liver and effects on muscle glucose metabolism

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Why the study?

Does maintaining basal insulin levels during exercise affect whole body glucose fluxes and muscle glucose metabolism in dogs?

Population

Dogs with chronic placement of sampling and infusion catheters, undergoing 90 min of moderate treadmill…

Comparison

Somatostatin infusion to suppress insulin and… vs Somatostatin infusion with exercise-stimulated…

Design

Preclinical

Follow-up

90 minutes

Authors

BZB. A. ZinkerAbbott FundTMThomas MohrUniversity of ViennaPKPatrick C. KellyGoethe University Frankfurt

Discussion

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Overview

Maintaining basal insulin does not alter exercise glucose fluxes in this canine model; leaves open relevance to human physiology and clinical recommendations.

Structured PICO

Does maintaining basal insulin levels during exercise affect whole body glucose fluxes and muscle glucose metabolism in dogs?

P
Population
Dogs (n=14) with chronic placement of sampling and infusion catheters, undergoing 90 min of moderate treadmill exercise
I
Intervention
Somatostatin (SRIF) infusion to suppress insulin and glucagon, with basal insulin replacement (B-INS, n=6)
C
Comparator
Somatostatin (SRIF) infusion with exercise-stimulated insulin replacement (S-INS, n=8)
O
Outcome
Whole body glucose production (Ra) and disappearance (Rd), hindlimb glucose uptake, and hindlimb oxidative and nonoxidative glucose metabolismsurrogate

Maintaining basal insulin levels during exercise does not affect exercise-induced increases in whole body glucose fluxes and hindlimb glucose metabolism in dogs when glucagon is suppressed.

Cite This Study

Zinker et al. (1994) studied this question.

synapsesocial.com/papers/6a75fd03db3f4160f98b78eahttps://doi.org/10.1152/ajpendo.1994.266.5.e683
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise-Induced Fall in Insulin and Increase in Fat Metabolism During Prolonged Muscular Work1989 · 77 citations
  2. 2Kinetics of In Vivo Muscle Insulin-Mediated Glucose Uptake in Human Obesity1990 · 96 citations
  3. 3Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs.1984 · 113 citations
  4. 4Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog.1987 · 181 citations
  5. 5Impact of Insulin Deficiency on Glucose Fluxes and Muscle Glucose Metabolism During Exercise1992 · 45 citations