Key result
Clamping insulin at basal levels during exercise in dogs completely prevents the arterial free-fatty acid rise.
Why the study?
The role of the exercise-induced fall in insulin in fat metabolism during prolonged muscular work was unclear.
Does preventing the exercise-induced fall in insulin alter fat metabolism in dogs during prolonged muscular work?
Population
Dogs undergoing 150 min of treadmill exercise
Comparison
Exercise alone vs insulin clamped at basal levels with glucagon supplementation and glucose clamped
Design
Preclinical experimental study with intraportal infusions
Follow-up
150 min
Authors
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The fall in insulin is essential for FFA mobilization during canine exercise; leaves open translation to human physiology.
Does preventing the exercise-induced fall in insulin alter fat metabolism in dogs during prolonged muscular work?
Absolute Event Rate: -12% vs 644%
The exercise-induced fall in insulin is essential for the transition to increased free fatty acid metabolism during prolonged muscular work.
Wasserman et al. (1989) studied Exercise-induced fat metabolism. Insulin clamped at basal levels by intraportal infusion vs. Exercise alone (controls) was evaluated on Change in arterial free-fatty acid (FFA) levels. Clamping insulin at basal levels during 150 minutes of treadmill exercise in dogs prevented the normal exercise-induced rise in arterial free-fatty acid levels (-12 ± 148 vs 644 ± 126 μeq/L).
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