January 1, 1990Diabetes Care
Variation in Absorption of NPH Insulin Due to Intramuscular Injection
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Discussion
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Implication
Randomized trial evaluates how intramuscular injection affects insulin absorption, indicating risks of this method.
Key Points
- This study aims to understand the effects of accidental intramuscular injection of NPH insulin on absorption rates in patients with diabetes.
- Measured disappearance rates of 125I-labeled NPH insulin from subcutaneous and intramuscular sites in 11 patients.
- Conducted four measurements for each patient at both injection sites.
- Analyzed coefficients of variation for absorption rates over multiple days.
- Intramuscular absorption rate of NPH insulin was significantly faster (T50% = 5.3 h) compared to subcutaneous (T50% = 10.3 h, P<0.0001).
- Intrapatient variation was lower for subcutaneous (C.V. T50% = 18.4%) than intramuscular (C.V. T50% = 29.8%, P<0.01).
- Subcutaneous injection had lower day-to-day variation compared to interpatient variation (C.V. T50% = 50%, P<0.0001).
Cite This Study
Vaag et al. (1990) studied this question.