Key result
Targeted overexpression of elafin protected mice against viral myocarditis, reducing 11-day mortality to 1 of 9 transgenic mice compared with 10 of 12 nontransgenic littermates.
Why the study?
Does targeted overexpression of elafin prevent mortality and cardiac dysfunction in mice following viral myocarditis?
Does targeted overexpression of elafin prevent mortality and cardiac dysfunction in mice following viral myocarditis?
Absolute Event Rate: 11.1% vs 83.3%
Targeted overexpression of elafin in the cardiovascular system significantly reduces mortality and preserves cardiac function in a murine model of viral myocarditis.
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Elafin overexpression protects against myocarditis-induced cardiac injury in mice; leaves open whether elastase inhibition merits human investigation.
Zaidi et al. (1999) studied Viral myocarditis (n=21). Targeted overexpression of elafin vs. Nontransgenic littermates was evaluated on Mortality within 11 days. Targeted overexpression of elafin protected mice against viral myocarditis, reducing 11-day mortality to 1 of 9 transgenic mice compared with 10 of 12 nontransgenic littermates.
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