Key result
Patients with chronic orthostatic intolerance had a greater decrease in norepinephrine clearance with standing compared to control subjects (55% vs 30%, P<0.02).
Why the study?
Do patients with chronic orthostatic intolerance have functional abnormalities in autonomic neurons regulating cardiovascular responses compared to healthy controls?
Population
13 patients with chronic orthostatic intolerance (OI) and 10 control subjects
Comparison
Autonomic testing including systemic… vs Control subjects
Design
Case-control
Authors
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Supports autonomic neuronal abnormalities in OI; leaves open primary vs secondary role and therapeutic implications.
Case-Control (n=23)
Do patients with chronic orthostatic intolerance have functional abnormalities in autonomic neurons regulating cardiovascular responses compared to healthy controls?
Absolute Event Rate: 55% vs 30%
p-value: p=<0.02
Patients with chronic orthostatic intolerance exhibit disordered sympathetic cardiovascular regulation, characterized by decreased norepinephrine clearance upon standing and increased sensitivity to adrenergic agonists.
Jacob et al. (1999) conducted a case-control in Chronic orthostatic intolerance (n=23). Chronic orthostatic intolerance vs. Control subjects was evaluated on Decrease in norepinephrine clearance with standing (p=<0.02). Patients with chronic orthostatic intolerance had a greater decrease in norepinephrine clearance with standing compared to control subjects (55% vs 30%, P<0.02).
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