July 1, 1985Annals of Neurology
Decreased sympathetic neuronal uptake in idiopathic orthostatic hypotension
Key result
Idiopathic orthostatic hypotension is linked to lower plasma norepinephrine levels, clearance, and release rates.
Why the study?
How do the plasma disappearance rates and clearance of norepinephrine differ between normal subjects, patients with multiple-system atrophy, and patients with idiopathic orthostatic hypotension?
Population
Normal subjects and patients with either multiple-system atrophy or idiopathic orthostatic hypotension
Comparison
Intravenous administration of… vs Comparisons between normal subjects, MSA…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports distinguishing idiopathic orthostatic hypotension from multiple-system atrophy via norepinephrine kinetics; hypothesis-generating for autonomic phenotyping.
Study Design
Type
Observational
Structured PICO
How do the plasma disappearance rates and clearance of norepinephrine differ between normal subjects, patients with multiple-system atrophy, and patients with idiopathic orthostatic hypotension?
P
Population
Normal subjects and patients with either multiple-system atrophy (MSA) or idiopathic orthostatic hypotension (IOH)
E
Exposure
Intravenous administration of levo-norepinephrine (l-NE), dextro-norepinephrine (d-NE), and isoproterenol (ISO)
C
Comparator
Comparisons between normal subjects, MSA patients, and IOH patients
O
Outcome
Disappearance rates of l-NE, d-NE, and ISO from plasmasurrogate
The study demonstrates that idiopathic orthostatic hypotension involves decreased sympathetic neuronal norepinephrine release and clearance, distinguishing its peripheral autonomic pathophysiology from the central dysfunction in multiple-system atrophy.
Cite This Study
Polinsky et al. (1985) conducted an observational in Idiopathic orthostatic hypotension and multiple-system atrophy. Idiopathic orthostatic hypotension (IOH) vs. Normal subjects was evaluated on Plasma norepinephrine levels, clearance, and apparent release rate. Patients with idiopathic orthostatic hypotension had significantly lower plasma norepinephrine levels, clearance, and apparent release rates compared to normal subjects.