Key result
Carotid plaque area was a stronger predictor of first-ever MI in women (RR 3.95; 95% CI 2.16-7.19) than in men (RR 1.56; 95% CI 1.04-2.36).
Why the study?
Does carotid atherosclerosis (plaque area and IMT) predict first-ever myocardial infarction differently in men and women?
Population
6,226 men and women aged 25 to 84 years from a general population with no previous myocardial infarction.
Comparison
Carotid ultrasound measuring intima media… vs No carotid plaque or lowest IMT quartile.
Design
Cohort
Follow-up
6 years
Authors
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May inform sex-specific MI risk assessment in women; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=6,226)
Does carotid atherosclerosis (plaque area and IMT) predict first-ever myocardial infarction differently in men and women?
Relative Risk: 3.95 (95% CI 2.16–7.19)
Carotid plaque area is a stronger predictor of first-ever myocardial infarction than intima media thickness, and this risk association is significantly more pronounced in women than in men.
Johnsen et al. (2007) conducted a cohort in no previous MI (n=6,226). Carotid plaque area vs. no plaque was evaluated on first-ever myocardial infarction (MI) (RR 3.95, 95% CI 2.16 to 7.19). Carotid plaque area was a stronger predictor of first-ever MI in women (RR 3.95; 95% CI 2.16-7.19) than in men (RR 1.56; 95% CI 1.04-2.36).
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