Key result
A mock heart engineered with helical aramid fibers achieved physiological ventricular torsion angles (15°-26°) and pressure-volume loops, serving as a platform for cardiovascular device testing.
The developed mock heart circulation loop successfully mimics physiological ventricular torsion and pressure-volume loops, providing a comprehensive in vitro testing platform for cardiovascular devices such as ventricular assist devices and artificial heart valves.
Enhances physiological fidelity of in vitro VAD testing platforms; leaves open translation to clinical device performance.
Mock heart circulation loops (MHCLs) serve as in-vitro platforms to investigate the physiological interaction between circulatory systems and cardiovascular devices. A mock heart (MH) engineered with silicone walls and helical aramid fibers, to mimic the complex contraction of a natural heart, has been developed to advance the MHCL previously developed in our group. A mock aorta with an anatomical shape enables the evaluation of a cannulation method for ventricular assist devices (VADs) and investigation of the usage of clinical measurement systems like pressure-volume catheters. Ventricle and aorta molds were produced based on MRI data and cast with silicone. Aramid fibers were layered in the silicone ventricle to reproduce ventricle torsion. A rotating hollow shaft was connected to the apex enabling the rotation of the MH and the connection of a VAD. Silicone wall thickness, aramid fiber angle and fiber pitch were varied to generate different MH models. All MH models were placed in a tank filled with variable amounts of water and air simulating the compliance. In this work, physiological ventricular torsion angles (15°-26°) and physiological pressure-volume loops were achieved. This MHCL can serve as a comprehensive testing platform for cardiovascular devices, such as artificial heart valves and cannulation of VADs.
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Jansen‐Park et al. (2017) studied Cardiovascular device testing. Mock heart engineered with silicone walls and helical aramid fibers was evaluated on Physiological ventricular torsion angles and pressure-volume loops. A mock heart engineered with helical aramid fibers achieved physiological ventricular torsion angles (15°-26°) and pressure-volume loops, serving as a platform for cardiovascular device testing.
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