The reaction of equivalent amounts of benzyloxycarbonyl-L-valine and NN′-di-isopropylcarbodi-imide in deuteriochloroform at room temperature is very fast and clean giving an O-acylisourea adduct which is stable in solution for many hours and which has been characterised by n.m.r. spectroscopy.
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Bates et al. (1980) studied this question.
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