Key result
In spontaneously hypertensive rats, 2 weeks of Tempol therapy significantly decreased mean arterial pressure compared to control (162 vs 191 mmHg, P<0.05), an effect abolished by L-NAME.
Why the study?
Does Tempol reduce blood pressure and oxidative stress in spontaneously hypertensive rats in the presence or absence of NO synthase inhibition?
Does Tempol reduce blood pressure and oxidative stress in spontaneously hypertensive rats in the presence or absence of NO synthase inhibition?
Absolute Event Rate: 162% vs 191%
p-value: p=< 0.05
In spontaneously hypertensive rats, the antioxidant Tempol reduces oxidative stress regardless of NO levels, but requires NO to lower blood pressure.
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Tempol may lower BP via NO-dependent mechanisms in hypertensive rats; hypothesis-generating for human translation.
Yanes et al. (2004) studied Hypertension (Spontaneously hypertensive rats). Tempol vs. Control was evaluated on Mean arterial pressure (MAP) (p=< 0.05). In spontaneously hypertensive rats, 2 weeks of Tempol therapy significantly decreased mean arterial pressure compared to control (162 vs 191 mmHg, P<0.05), an effect abolished by L-NAME.
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