Key result
Larger subcutaneous abdominal adipocyte size predicted a higher incidence of type 2 diabetes in middle-aged women (HR 1.91 per 1 SD increase; P<0.001).
Why the study?
Does subcutaneous abdominal adipocyte size predict the incidence of type 2 diabetes in middle-aged women?
Population
245 middle-aged women from a population-based Swedish cohort who underwent adipose tissue needle biopsy for…
Design
Cohort
Follow-up
from 1974-1975 until 2001
Authors
Loading...
Larger abdominal adipocytes may flag higher T2D risk in women; extends Pima findings to Europeans but leaves causality and clinical utility open.
Cohort (n=245)
Does subcutaneous abdominal adipocyte size predict the incidence of type 2 diabetes in middle-aged women?
Hazard Ratio: 1.91
p-value: p=<0.001
Subcutaneous abdominal adipocyte size is a strong, independent predictor of future type 2 diabetes incidence in women, independent of body fat percentage and waist-to-height ratio.
Lönn et al. (2009) conducted a cohort in Type 2 diabetes (n=245). Subcutaneous abdominal adipocyte size vs. Smaller adipocyte size was evaluated on Incidence of type 2 diabetes (HR 1.91, p=<0.001). Larger subcutaneous abdominal adipocyte size predicted a higher incidence of type 2 diabetes in middle-aged women (HR 1.91 per 1 SD increase; P<0.001).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: