Key result
Surgically-induced complete heart block via AV node cauterization in rats achieved a 70% survival rate and led to significant electrophysiological, hemodynamic, and structural remodeling at 30 days.
Population
60 adult rats
Design
Preclinical
Follow-up
30 days
Authors
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Rat CHB model aids preclinical pacemaker alternatives; hypothesis-generating, requires validation before clinical consideration.
Surgically-induced complete heart block in rats is a reproducible model that leads to electrophysiological, hemodynamic, and structural remodeling culminating in chronic heart failure.
Cunha et al. (2014) studied Complete heart block (n=60). Surgically-induced complete heart block via AV node cauterization was evaluated on Survival rate. Surgically-induced complete heart block via AV node cauterization in rats achieved a 70% survival rate and led to significant electrophysiological, hemodynamic, and structural remodeling at 30 days.
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