August 1, 1998Journal of Applied Physiology
Development of a model of complete heart block in rats
Why the study?
Does targeted myocardial injection of 70% ethanol produce a reproducible model of permanent complete heart block in rats?
Population
Rats (n=57 total: 28 in initial ethanol group, 15 in saline control group, 14 in recovery group)
Comparison
Injection of 70% ethanol into the myocardium 3… vs Saline injection
Design
Preclinical
Follow-up
Up to 7 days
Authors
Discussion
Loading...
Member takes
Implication
This rat model enables preclinical conduction disease studies; clinical translation remains premature without human validation.
Structured PICO
Does targeted myocardial injection of 70% ethanol produce a reproducible model of permanent complete heart block in rats?
P
Population
Rats (n=57 total: 28 in initial ethanol group, 15 in saline control group, 14 in recovery group)
I
Intervention
Injection of 70% ethanol (5-10 microl) into the myocardium 3 mm below the epicardial surface using an epicardial fat pad as a landmark
C
Comparator
Saline injection
O
Outcome
Production of stable, complete heart blocksurrogate
Targeted ethanol injection into the rat myocardium provides a simple, highly reproducible preclinical model for permanent, complete heart block.
Cite This Study
Lee et al. (1998) studied this question.