Why the study?
A reliable animal model of complete atrioventricular block is essential for understanding the mechanisms underlying the fatal hemodynamic effects and electrical conductivity alterations associated with this arrhythmia.
Does a 70% ethanol injection in the AV node induce complete atrioventricular block in Sprague Dawley rats?
Population
Eight Sprague Dawley rats (8 weeks old, 220 ± 30 g)
Comparison
70% ethanol injection in the AV node vs 0.9% sodium chloride injection
Design
Preclinical animal model study
Follow-up
7 and 14 days
Authors
Loading...
Provides a reproducible rat model for complete AVB; leaves open translation to larger animals or clinical use.
Does a 70% ethanol injection in the AV node induce complete atrioventricular block in Sprague Dawley rats?
A 70% ethanol injection into the AV node via partial sternotomy is a reliable and reproducible method to create a complete atrioventricular block model in rats.
Elgalad et al. (2023) studied this question.