May 1, 1992Pacing and Clinical Electrophysiology
Permanent AV Block or Modification of AV Nodal Function by Selective AV Nodal Artery Ethanol Infusion
Why the study?
Does selective AV nodal artery ethanol infusion modify or ablate AV nodal function in dogs?
Population
9 closed chest anesthetized dogs
Design
Preclinical
Follow-up
4 weeks
Authors
Discussion
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Implication
Provides proof-of-concept for ethanol AV nodal modification in dogs; hypothesis-generating and requires clinical validation before any human application.
Structured PICO
Does selective AV nodal artery ethanol infusion modify or ablate AV nodal function in dogs?
P
Population
9 closed chest anesthetized dogs
I
Intervention
Selective AV nodal artery ethanol infusion (25%, 50%, or 100% ethanol in normal saline) at 0.5 mL/min for 10 minutes via a 2.2 French infusion catheter
O
Outcome
Acute and chronic effects on AV nodal function (AV block, effective refractory period, Wenckebach cycle length) at up to 4 weekssurrogate
Selective AV nodal artery ethanol infusion causes localized necrosis and persistent AV nodal modification or ablation in dogs, suggesting a potential alternative for patients failing standard ablation techniques.
Cite This Study
Wang et al. (1992) studied this question.