Key result
The decrease in the slope of the stroke work vs end-diastolic length relationship with 30 minutes of ischemia exceeded the decrease with 20 minutes by 29% in the right ventricle and 32% in the left (p<0.04).
Why the study?
Does the slope of the linear stroke work versus end-diastolic length relationship provide a valid index of ventricular contractile response to global ischemia in an intact heart model?
Does the slope of the linear stroke work versus end-diastolic length relationship provide a valid index of ventricular contractile response to global ischemia in an intact heart model?
p-value: p=<0.04
The slope of the linear stroke work versus end-diastolic length relationship is a valid, load-independent index of right and left ventricular contractile response to global ischemia in the intact circulation.
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Sonomicrometric work-length index offers precise contractile assessment in canine ischemia models; leaves open translation to clinical ventricular monitoring.
Morris et al. (1987) studied Global cardiac ischemia (n=20). Global cardiac ischemia vs. 20 min was evaluated on Slope (Mw) of the linear stroke work vs end-diastolic length relationship (p=<0.04). The decrease in the slope of the stroke work vs end-diastolic length relationship with 30 minutes of ischemia exceeded the decrease with 20 minutes by 29% in the right ventricle and 32% in the left (p<0.04).