Key result
In mice post-MI, cyclic angiotensin-(1-7) increased progenitor cells at 24 hours but reduced cardiac capillary density at 3 weeks and did not alter cardiovascular function at 9 weeks.
Why the study?
Does cyclic angiotensin-(1-7) improve progenitor cell recruitment and cardiovascular function post-myocardial infarction in mice?
Does cyclic angiotensin-(1-7) improve progenitor cell recruitment and cardiovascular function post-myocardial infarction in mice?
Cyclic angiotensin-(1-7) recruits progenitor cells early after MI but exerts antiangiogenic effects, suggesting its optimal use depends on the timing of administration.
Cyclic Ang-(1-7) may enhance post-MI progenitor recruitment in mice; leaves open translation to human therapy.
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Pessôa et al. (2015) studied Myocardial infarction. Cyclic angiotensin-(1-7) vs. Saline was evaluated on Progenitor cell recruitment, cardiovascular function, and cardiac histology. In mice post-MI, cyclic angiotensin-(1-7) increased progenitor cells at 24 hours but reduced cardiac capillary density at 3 weeks and did not alter cardiovascular function at 9 weeks.
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