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October 1, 1985Annual Review of Physiology

Kinetic Properties of the Plasma Membrane Na+ -H+ Exchanger

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Authors

PAPeter S. AronsonYale University

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Implication

Basic transport properties of Na+-H+ exchanger influence pH regulation in various cell types.

Key Points

  • This research aims to explore the kinetic characteristics of the Na+-H+ exchanger and its role in cellular functions.
  • Analyzed transport mechanisms and stoichiometry of Na+-H+ exchanger.
  • Examined the effects of various cations including Na+, Li+, and NH4+ on exchanger kinetics.
  • Utilized kinetic models to assess cation-hydroxyl cotransport and cation-proton exchange mechanisms.
  • Na+-H+ exchanger exhibits greater than first-order dependence on intracellular H+ concentration.
  • Transport efficiency demonstrated sensitivity to varying concentrations of Na+, Li+, and NH4+.
  • Kinetic models suggest mechanisms for intracellular pH regulation through the Na+-H+ exchanger.

Cite This Study

Peter S. Aronson (1985) studied this question.

synapsesocial.com/papers/6a6a5d7e2ef98b0efacb227ehttps://doi.org/10.1146/annurev.ph.47.030185.002553
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microfluorometric monitoring of pHi in cultured heart cells: Na+-H+ exchange1983 · 58 citations
  2. 2Interaction of external H+ with the Na+-H+ exchanger in renal microvillus membrane vesicles.1983 · 201 citations
  3. 3Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange1983 · 111 citations
  4. 4Sodium/proton exchange in mouse neuroblastoma cells.1981 · 167 citations
  5. 5Volume-responsive sodium movements in dog red blood cells1983 · 101 citations