Key result
Renin-based treatment modification in patients with resistant hypertension significantly reduced mean systolic blood pressure from 163 mm Hg to 140 mm Hg (P<0.0001).
Why the study?
Does renin-based treatment modification improve blood pressure control in patients with resistant hypertension?
Population
73 outpatients with hypertension resistant to treatment with one or more agents referred to a hypertension…
Comparison
Antihypertensive treatment modification based on… vs Baseline.
Design
Cohort
Follow-up
1-year
Authors
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Current hypertension strategies remain inadequate; leaves open need for refined BP protocols in practice and trials.
Cohort (n=73)
No
Does renin-based treatment modification improve blood pressure control in patients with resistant hypertension?
Absolute Event Rate: 140% vs 163%
p-value: p=<.0001
Tailoring antihypertensive therapy based on plasma renin activity profiling can significantly improve blood pressure control while reducing the number and cost of medications in patients with resistant hypertension.
Blumenfeld et al. (1998) conducted a cohort in Resistant hypertension (n=73). Renin-based analysis and treatment modification vs. Baseline (prior to treatment modification) was evaluated on Systolic blood pressure (mm Hg) (p=<.0001). Renin-based treatment modification in patients with resistant hypertension significantly reduced mean systolic blood pressure from 163 mm Hg to 140 mm Hg (P<0.0001).
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