Key result
Avoidance of postoperative anticoagulation following mitral valve repair or bioprosthetic replacement did not significantly impact overall survival compared to warfarin therapy (86% vs 84%; P=0.79).
Why the study?
Does avoiding postoperative anticoagulation (warfarin) increase the risk of stroke or mortality in patients undergoing mitral valve repair or bioprosthetic replacement?
Cohort (n=249)
Does avoiding postoperative anticoagulation (warfarin) increase the risk of stroke or mortality in patients undergoing mitral valve repair or bioprosthetic replacement?
Absolute Event Rate: 86% vs 84%
p-value: p=0.79
Avoiding postoperative warfarin after mitral valve repair or bioprosthetic replacement does not increase perioperative complications or impact intermediate survival, challenging current guidelines.
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May support omitting anticoagulation after MVRR/BMVR without other indications; leaves open need for randomized confirmation.
Schwann et al. (2013) conducted a cohort in Mitral valve repair or bioprosthetic mitral valve replacement (n=249). Avoidance of postoperative anticoagulation vs. Warfarin therapy was evaluated on Overall survival (p=0.79). Avoidance of postoperative anticoagulation following mitral valve repair or bioprosthetic replacement did not significantly impact overall survival compared to warfarin therapy (86% vs 84%; P=0.79).
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