Key result
Carotid body overactivity contributes to the pathogenesis of metabolic syndrome, and its pharmacological manipulation represents a potential therapeutic target for cardiometabolic diseases.
Why the study?
Carotid body malfunction and resulting sympathetic overactivation may contribute to metabolic syndrome, but the metabolic role and potential therapeutic targets of the carotid body need synthesis.
Pharmacological manipulation of carotid body activity may offer potential therapeutic benefits for cardiometabolic diseases like metabolic syndrome.
CB overactivation may link to metabolic syndrome; leaves open whether modulation improves outcomes in patients.
The carotid body (CB) is responsible for the peripheral chemoreflex by sensing blood gases and pH. The CB also appears to act as a peripheral sensor of metabolites and hormones, regulating the metabolism. CB malfunction induces aberrant chemosensory responses that culminate in the tonic overactivation of the sympathetic nervous system. The sympatho-excitation evoked by CB may contribute to the pathogenesis of metabolic syndrome, inducing systemic hypertension, insulin resistance and sleep-disordered breathing. Several molecular pathways are involved in the modulation of CB activity, and their pharmacological manipulation may lead to overall benefits for cardiometabolic diseases. In this review, we will discuss the role of the CB in the regulation of metabolism and in the pathogenesis of the metabolic dysfunction induced by CB overactivity. We will also explore the potential pharmacological targets in the CB for the treatment of metabolic syndrome.
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Kim et al. (2020) conducted a review in Metabolic syndrome. Pharmacological manipulation of carotid body activity was evaluated. Carotid body overactivity contributes to the pathogenesis of metabolic syndrome, and its pharmacological manipulation represents a potential therapeutic target for cardiometabolic diseases.
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