Key result
Intramyocardial injections of a degradable ELRs-hydrogel led to a 16.2% average improvement in ejection fraction 21 days after intervention in an ovine model of non-transmural myocardial infarction.
Why the study?
Does elastin-like recombinamers-based hydrogel injection improve post-ischemic remodeling and functional recovery in a sheep model of non-transmural myocardial infarction?
Population
Sheep with non-transmural myocardial infarction
Comparison
ELRs-hydrogel injection
Design
Preclinical animal study
Authors
Loading...
May support hydrogel therapy for post-MI remodeling in large animals; leaves open human translation and should not change practice.
Does elastin-like recombinamers-based hydrogel injection improve post-ischemic remodeling and functional recovery in a sheep model of non-transmural myocardial infarction?
Absolute Event Rate: 16.2% vs -2.6%
p-value: p=<0.01
Injection of an elastin-like recombinamers-based hydrogel improves functional recovery and cardiomyocyte preservation in a large animal model of myocardial infarction, suggesting potential for future clinical translation.
Contessotto et al. (2021) studied Non-transmural myocardial infarction (NSTEMI) (n=39). Elastin-like recombinamers-based hydrogel (ELRs-hydrogel) vs. PBS injection or untreated (MI-only) was evaluated on Ejection fraction (EF) recovery 21 days after intervention (p=<0.01). Intramyocardial injections of a degradable ELRs-hydrogel led to a 16.2% average improvement in ejection fraction 21 days after intervention in an ovine model of non-transmural myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: