Key result
Oral administration of egg protein-derived peptide QIGLF markedly reduced systolic blood pressure in spontaneously hypertensive rats.
Why the study?
Does orally administered egg protein-derived peptide QIGLF reduce blood pressure in spontaneously hypertensive rats?
Does orally administered egg protein-derived peptide QIGLF reduce blood pressure in spontaneously hypertensive rats?
The egg protein-derived peptide QIGLF demonstrates in vivo antihypertensive effects by lowering systolic blood pressure in a rat model, suggesting potential utility in hypertension management.
QIGLF shows antihypertensive activity in SHRs; leaves open translation to human hypertension therapy.
BACKGROUND: The present study aimed to investigate the in vivo antihypertensive effect on spontaneously hypertensive rats (SHRs) induced by egg protein-derived peptide QIGLF, which has been previously characterized in vitro as a potent angiotensin-converting enzyme inhibitor. RESULTS: In vivo antihypertensive effect of QIGLF orally administered was evaluated by the tail-cuff method. The systolic blood pressure and the diastolic blood pressure of rats were measured 0, 5, 10, 15 and 20 h after administration every day. Subsequently, the effect of QIGLF on angiotensin-converting enzyme mRNA expression in the kidney of SHRs was evaluated by a polymerase chain reaction. Systolic blood pressure was found to be reduced markedly in the SHRs after a single oral administration. CONCLUSION: body weight) with respect to lowering systolic blood pressure in SHRs. Therefore, egg white protein-derived peptide QIGLF may be useful in the prevention or treatment of hypertension.
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Yu et al. (2016) studied Hypertension (spontaneously hypertensive rats). Egg protein-derived peptide QIGLF was evaluated on Systolic and diastolic blood pressure. Oral administration of egg protein-derived peptide QIGLF markedly reduced systolic blood pressure in spontaneously hypertensive rats.
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