Key result
Administration of peptide RVPSL for 4 weeks significantly decreased blood pressure and mRNA levels of renin, ACE, and AT1 receptor in spontaneously hypertensive rats compared to the negative group.
Why the study?
Does peptide RVPSL reduce blood pressure in spontaneously hypertensive rats?
Does peptide RVPSL reduce blood pressure in spontaneously hypertensive rats?
The egg-derived peptide RVPSL demonstrates antihypertensive effects in a rat model by downregulating components of the renin-angiotensin system.
Hypothesis-generating for egg-derived peptides in hypertension; human trials needed before any clinical consideration.
Hen eggs are well-known for their biological functions beyond basic nutrition. In this study, the antihypertensive effect of peptide RVPSL from egg protein has been evaluated by an in vivo model. In addition, the mRNA levels of renin, AT1 receptor, angiotensin-converting enzyme (ACE), and AT2 receptor in the rat kidney were investigated through real-time polymerase chain reaction. The Ang I, Ang II, renin, and aldosterone concentrations of serum were also measured. Our results indicated that the blood pressure of the spontaneously hypertensive rats administered RVPSL for 4 weeks decreased significantly compared to that of the negative group. The mRNA levels of renin, ACE, and AT1 receptor in kidney also decreased significantly. The serum Ang II, renin, and aldosterone concentrations of the treatment group were reduced in comparison to those of the negative group. It is hoped this study will help our understanding and potential use of RVPSL in the treatment or prevention of hypertension.
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Yu et al. (2014) studied Hypertension. Peptide RVPSL vs. Negative group was evaluated on Blood pressure. Administration of peptide RVPSL for 4 weeks significantly decreased blood pressure and mRNA levels of renin, ACE, and AT1 receptor in spontaneously hypertensive rats compared to the negative group.
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